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1,2,4-Triazines Are Versatile Bioorthogonal Reagents.
- Source :
-
Journal of the American Chemical Society . 7/8/2015, Vol. 137 Issue 26, p8388-8391. 4p. - Publication Year :
- 2015
-
Abstract
- A new class of bioorthogonal reagents, 1,2,4-triazines, is described. These scaffolds are stable in biological media and capable of robust reactivity with trans-cyclooctene (TCO). The enhanced stability of the triazine scaffold enabled its direct use in recombinant protein production. The triazine-TCO reaction can also be used in tandem with other bioorthogonal cycloaddition reactions. These features fill current voids in the bioorthogonal toolkit. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 137
- Issue :
- 26
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 108669603
- Full Text :
- https://doi.org/10.1021/jacs.5b05100