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Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder.
- Source :
-
Journal of Neurophysiology . 2/1/2015, Vol. 113 Issue 3, p709-719. 11p. - Publication Year :
- 2015
-
Abstract
- Reduced levels of gamma-band activity are present in schizophrenia and bipolar disorder patients. In the same disorders, increased neuronal calcium sensor protein-1 (NCS-1) expression was reported in a series of postmortem studies. These disorders are also characterized by sleep dysregulation, suggesting a role for the reticular activating system (RAS). The discovery of gamma-band activity in the pedunculopontine nucleus (PPN), the cholinergic arm of the RAS, revealed that such activity was mediated by high-threshold calcium channels that are regulated by NCS-1. We hypothesized that NCS-1 normally regulates gamma-band oscillations through these calcium channels and that excessive levels of NCS-1, such as would be expected with overexpression, decrease gamma- band activity. We found that PPN neurons in rat brain slices mani- fested gamma-band oscillations that were increased by low levels of NCS-1 but suppressed by high levels of NCS-1. Our results suggest that NCS-1 overexpression may be responsible for the decrease in gamma-band activity present in at least some schizophrenia and bipolar disorder patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223077
- Volume :
- 113
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Neurophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 108659497
- Full Text :
- https://doi.org/10.1152/jn.00828.2014