Lack of association between the 389 C> T polymorphism (rs769217) in the catalase ( CAT) gene and the risk of vitiligo: An update by meta-analysis.

Background/Objectives The catalase ( CAT) T/ C at codon 389 in the exon 9 polymorphism has been implicated in susceptibility to vitiligo but a large number of studies have reported inconclusive results. The purpose of this study is to evaluate the association between the catalase gene polymorphism (389 C> T) and the risk of vitiligo. Methods A meta-analysis was carried out to analyse the association between 389 C> T and vitiligo risk. Results Eight case-control studies with 2923 cases and 4237 controls were included in the meta-analysis. The results indicated that there was no association between this polymorphism and vitiligo ( TT + CT versus CC: OR = 1.08, 95% CI = 0.98-1.20, P = 0.11, T versus C: OR = 1.07, 95% CI = 0.99-1.16, P = 0.092). In a subgroup analysis by ethnicity, no significant association between the CAT gene 389 C> T polymorphism and vitiligo susceptibility was found in Caucasians ( TT + CT versus CC: OR = 1.15, 95% CI = 0.98-1.35, P = 0.08; T versus C: OR = 1.07, 95% CI = 0.97-1.19, P = 0.173) and Asians ( TT + CT versus CC: OR = 1.12, 95% CI =0.93-1.34, P = 0.23; T versus C: OR = 1.07, 95% CI = 0.94-1.21, P = 0.321). Conclusions Our results suggest that 389 C> T may not contribute to vitiligo susceptibility. However, larger primary studies with the consideration of gene-environment and gene-gene interactions are still required to further evaluate the interaction of CAT gene polymorphism with vitiligo susceptibility. [ABSTRACT FROM AUTHOR]