Causal or Noncausal Relationship of Uric Acid With Diabetes.

The article discusses the study "A Mendelian Randomization Study of Circulating Uric Acid and Type 2 Diabetes" by I. Slujis, M. V. Holmes, Y. T. van der Schouw and colleagues, published within the issue. Topics covered include the uric acid-insulin resistance hypothesis, the use of a genetic epidemiological approach known as Mendelian randomization, and the single nucleotide polymorphisms identified from genome-wide association studies.