CF3-Carbenoid C-H Functionalization of (Hetero)arenes under Chelation-Controlled RhIII Catalysis.

An efficient method for the CF3-carbenoid C-H functionalization of benzenes and indoles using readily available methyl 3,3,3-trifluoro-2-diazopropionate as a cross-coupling partner under chelation-controlled RhIII catalysis has been developed. The reactions proceeded smoothly with high regioselectivity in a few hours and allowed the simultaneous introduction of CF3 and carboxylate functions into the 2-position of directing-group-containing benzenes and indoles. [ABSTRACT FROM AUTHOR]