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Opinion: Vertebrate gene predictions and the problem of large genes.
- Source :
-
Nature Reviews Genetics . Sep2003, Vol. 4 Issue 9, p741-749. 9p. - Publication Year :
- 2003
-
Abstract
- To find unknown protein-coding genes, annotation pipelines use a combination of ab initio gene prediction and similarity to experimentally confirmed genes or proteins. Here, we show that although the ab initio predictions have an intrinsically high false-positive rate, they also have a consistently low false-negative rate. The incorporation of similarity information is meant to reduce the false-positive rate, but in doing so it increases the false-negative rate. The crucial variable is gene size (including introns) - genes of the most extreme sizes, especially very large genes, are most likely to be incorrectly predicted. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PROTEINS
*GENES
*MOLECULAR genetics
*HEREDITY
*DNA
Subjects
Details
- Language :
- English
- ISSN :
- 14710056
- Volume :
- 4
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Nature Reviews Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 10706626
- Full Text :
- https://doi.org/10.1038/nrg1160