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Vitreous levels of interleukin-6 and vascular endothelial growth factor are related to diabetic macular edema
- Source :
-
Ophthalmology . Sep2003, Vol. 110 Issue 9, p1690. 7p. - Publication Year :
- 2003
-
Abstract
- : PurposeTo investigate whether interleukin-6 (IL-6) or vascular endothelial growth factor (VEGF) is related to diabetic macular edema (DME) in subjects without posterior vitreous detachment (PVD).: DesignRetrospective case-control study.: ParticipantsTwenty-six subjects who had DME without PVD and 12 subjects who had nondiabetic ocular disease (the control group).: MethodsVitreous fluid samples were obtained at vitreoretinal surgery, and the IL-6 and VEGF levels in vitreous fluid and plasma were measured by enzyme-linked immunosorbent assay.: Main outcome measuresVitreous levels of IL-6 and VEGF in DME subjects without PVD.: ResultsThe vitreous levels of both IL-6 and VEGF were significantly higher in the subjects with DME than in control subjects (P<0.0001 and P<0.0001, respectively). The vitreous level of IL-6 was significantly correlated with that of VEGF (P<0.0001). Vitreous levels of both IL-6 and VEGF were significantly higher in subjects with hyperfluorescent DME than in those with minimally fluorescent DME (P = 0.0008 and P = 0.0038, respectively).: ConclusionsWe found that the levels of both IL-6 and VEGF were elevated in the vitreous fluid of subjects with hyperfluorescent DME. Our results suggest that IL-6 and VEGF may promote an increase of vascular permeability in DME subjects without PVD. Interleukin-6 may possibly induce an increase of vascular permeability through a paracrine effect on VEGF in these subjects. [Copyright &y& Elsevier]
- Subjects :
- *INTERLEUKIN-6
*VASCULAR endothelium
*PARACRINE mechanisms
Subjects
Details
- Language :
- English
- ISSN :
- 01616420
- Volume :
- 110
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 10633030
- Full Text :
- https://doi.org/10.1016/S0161-6420(03)00568-2