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The alpha-synuclein gene in multiple system atrophy.
- Source :
-
Journal of Neurology, Neurosurgery & Psychiatry . Apr2006, Vol. 77 Issue 4, p464-467. 4p. - Publication Year :
- 2006
-
Abstract
- <bold>Background: </bold>The formation of alpha-synuclein aggregates may be a critical event in the pathogenesis of multiple system atrophy (MSA). However, the role of this gene in the aetiology of MSA is unknown and untested.<bold>Method: </bold>The linkage disequilibrium (LD) structure of the alpha-synuclein gene was established and LD patterns were used to identify a set of tagging single nucleotide polymorphisms (SNPs) that represent 95% of the haplotype diversity across the entire gene. The effect of polymorphisms on the pathological expression of MSA in pathologically confirmed cases was also evaluated.<bold>Results and Conclusion: </bold>In 253 Gilman probable or definite MSA patients, 457 possible, probable, and definite MSA cases and 1472 controls, a frequency difference for the individual tagging SNPs or tag-defined haplotypes was not detected. No effect was observed of polymorphisms on the pathological expression of MSA in pathologically confirmed cases. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223050
- Volume :
- 77
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Neurology, Neurosurgery & Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 106324095
- Full Text :
- https://doi.org/10.1136/jnnp.2005.073528