A Single Amino Acid Difference between α and β Ca[sup 2+]/Calmodulin-dependent Protein Kinase Dictates Sensitivity to the Specific Inhibitor, STO-609.

Authors :: Takumitsu, Hiroshi
Inuzuka, Hiroyuki
Ishikawa, Yumi
Kobayashi, Ryoji
Source :: Journal of Biological Chemistry. 3/28/2003, Vol. 278 Issue 13, p10908. 6p. 3 Diagrams, 2 Graphs.
Publication Year :: 2003
Abstract: Characterizes the inhibitory mechanism of STO-609, a selective inhibitor of Ca[sup 2+]/calmodulin-dependent protein kinase (CaM-KK), by using catalytic chimera and point mutants of CaM-KKalpha and CaM-KKbeta. Amino acid difference in the adenosine triphosphate-binding hydrophobic pocket of the catalytic domain of CaM-KK isoforms; Sensitivity of CaM-KK isoforms to STO-609.

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