MAPK Signaling Up-regulates the Activity of Hypoxia-inducible Factors by Its Effects on p300.

Authors :: Nianli Sang
Stiehl, Daniel P.
Bohensky, Jolene
Leshchinsky, Irene
Srinivas, Vickram
Caro, Jaime
Source :: Journal of Biological Chemistry. 4/18/2003, Vol. 278 Issue 16, p14013. 7p. 17 Black and White Photographs, 2 Diagrams, 17 Graphs.
Publication Year :: 2003
Abstract: Examines the molecular basis for hypoxia-inducible factor (HIF) activation by mitogen-activated protein kinase (MAPK). Disruption of the HIF-p300 interaction through MAPK inhibition; Suppression of the transactivation activity of p300; Degradation of HIF-alpha.

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