Isolation, Structural Characterization, and Properties of Mattacin (Polymyxin M), a Cyclic Peptide Antibiotic Produced by Paenibacillus kobensis M.

Discusses the isolation, structural characterization and properties of mattacin (polymyxin M), a cyclic peptide antibiotic produced by Paenibacillus kobensis M. Results of transfer NOE experiments on the conformational preferences of mattacin when bound to lipid A; Inhibition of the growth of a wide variety of Gram-positive and Gram-negative bacteria.