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Validation of the association between PSMA6 -8 C/G polymorphism and type 2 diabetes mellitus in Chinese Dongxiang and Han populations.
- Source :
-
Diabetes Research & Clinical Practice . Nov2012, Vol. 98 Issue 2, p295-301. 7p. - Publication Year :
- 2012
-
Abstract
- OBJECTIVE: The aim of our study was to validate association between -8 C/G variant of PSMA6 gene and T2DM in Chinese Dongxiang and Han populations. METHOD: We genotyped PSMA6 gene -8 C/G polymorphism in the control groups and T2DM groups in two populations from China using PCR-RFLP technique. Phenotypes and biochemical indicators were measured by biochemical technique. RESULT: The frequencies of CG+GG genotype were observably different from CC genotype in the T2DM groups and control groups (for Dongxiang population: OR=1.341, 95% CI: 1.101-1.632, P=0.004; for Han population: OR=1.313, 95% CI: 1.085-1.569, P=0.006 after adjusting for gender, age, and BMI, respectively). In the Dongxiang population, the FPG, HOMA-IR, SBP and TG levels of CG+GG genotype were markedly higher than those of the CC genotype in control group (all P<0.05). However, in the Han population, we only found that the FPI level of the CC genotype was significantly higher than that of the CG+GG genotype in control group (P<0.05). CONCLUSION: Our investigation suggests that -8 C/G variant of PSMA6 gene may be associated with T2DM and diabetes-related metabolic traits in Chinese Dongxiang and Han populations. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01688227
- Volume :
- 98
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Diabetes Research & Clinical Practice
- Publication Type :
- Academic Journal
- Accession number :
- 104392124
- Full Text :
- https://doi.org/10.1016/j.diabres.2012.09.021