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Stimulation of Cholesterol Excretion by the Liver X Receptor Agonist Requires ATP-binding Cassette Transporters G5 and G8.

Authors :
Liqing Yu
York, Jennifer
von Bergmann, Klaus
Lutjohann, Dieter
Cohen, Jonathan C.
Hobbs, Helen H.
Source :
Journal of Biological Chemistry. 5/2/2003, Vol. 278 Issue 18, p15565. 6p. 17 Graphs.
Publication Year :
2003

Abstract

Shows that stimulation of cholesterol excretion by the liver X receptor agonist requires adenosine triphosphate-binding cassette transporters G5 and G8. Role of ABCG5 and ABCG8 in enterohepatic sterol transport; Absence of significant effect of the LXR agonist on biliary cholesterol levels, fractional cholesterol absorption or neutral fecal sterol excretion.

Details

Language :
English
ISSN :
00219258
Volume :
278
Issue :
18
Database :
Academic Search Index
Journal :
Journal of Biological Chemistry
Publication Type :
Academic Journal
Accession number :
10433702
Full Text :
https://doi.org/10.1074/jbc.M301311200