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Specific antibodies contribute to the host protection against strains of Francisella tularensis subspecies holarctica
- Source :
-
Microbial Pathogenesis . Aug2003, Vol. 35 Issue 2, p73. 8p. - Publication Year :
- 2003
-
Abstract
- T cells are crucial to the control and eradication of the facultative intracellular bacterium Francisella tularensis. A contributory role of humoral antibodies in the host defence remains to be assessed. We used B-cell-deficient mice to study the possible contribution of antibodies to the defence against the live vaccine strain (LVS) or a clinical isolate of F. tularensis, both belonging to the subspecies holarctica (type B). When B-cell-deficient (Igμ−/−) mice of the C57BL/10 background were administered immune serum one day before intradermal injection of LVS, they developed lower bacterial numbers in skin, liver, and spleen than did mice receiving normal serum, and survived a challenge inoculum that was lethal for mice given normal serum. Administration of immune serum to C57BL/10 mice afforded protection also against infection with the clinical isolate of F. tularensis subsp. holarctica. Five days after intradermal inoculation of bacteria of the isolate, animals receiving immune serum showed <f>4 log10</f> lower bacterial counts in liver and spleen than mice administered normal serum. In mice primed by LVS infection, T-cell immunity and host protection were strong and only a marginal contribution of immune serum against a secondary intradermal infection was demonstrated. Together, these findings show that specific antibodies contribute to the host defence of mice against F. tularensis subsp. holarctica. [Copyright &y& Elsevier]
- Subjects :
- *T cells
*FRANCISELLA tularensis
*B cells
Subjects
Details
- Language :
- English
- ISSN :
- 08824010
- Volume :
- 35
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Microbial Pathogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 10424932
- Full Text :
- https://doi.org/10.1016/S0882-4010(03)00095-0