Liver-specific Deletion of the NADPH-Cytochrome P450 Reductase Gene.

Authors :: Gu, Jun
Yan Weng
Qing-Yu Zhang
Huadong Cui
Behr, Melissa
Lin Wu
Wiezhu Yang
Li Zhang
Xinxin Ding
Source :: Journal of Biological Chemistry. 7/11/2003, Vol. 278 Issue 28, p25895. 7p. 2 Diagrams, 4 Charts, 4 Graphs.
Publication Year :: 2003
Abstract: Discusses a mouse model with liver-specific deletion of cytochrome p450 reductase (CPR) gene. Reduction of CPR expression with corresponding decrease in liver microsomal cytochrome p450 (CYP); Increase of liver weight in the homozygotes; Absence of alternative redox partners for liver microsomal CYP.