Hierarchy of Polymorphic Variation and Desensitization Permutations Relative to β[sub 1]- and β[sub 2]-Adrenergic Receptor Signaling.

Proposes a general model whereby up to 10 levels of signaling by G-protein-coupled receptors can be present based on the influences of desensitization and genetic variation on coupling. Expression of four receptors in Chinese hamster fibroblasts at equivalent levels; Relative effects of genetic modifications and those of short term agonist-promoted desensitization on receptor function.