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Papel del factor de crecimiento transformador-beta (TGF-β) en la fisiopatología de la artritis reumatoide.
- Source :
-
Reumatología Clínica . May2014, Vol. 10 Issue 3, p174-179. 6p. - Publication Year :
- 2014
-
Abstract
- Transforming growth factor-beta (TGF-β) is a cytokine with pleiotropic functions in hematopoiesis, angiogenesis, cell proliferation, differentiation, migration and apoptosis. Although its role in rheumatoid arthritis is not well defined, TGF-β activation leads to functional immunomodulatory effects according to environmental conditions. The function of TGF-β in the development of arthritis in murine models has been extensively studied with controversial results. Recent findings point to a non-relevant role for TGF-p in a mice model of collagen-induced arthritis. The study of TGF-β on T-cell responses has shown controversial results as an inhibitor or promoter of the inflammatory response. This paper presents a review of the role of TGF-β in animal models of arthritis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Spanish
- ISSN :
- 1699258X
- Volume :
- 10
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Reumatología Clínica
- Publication Type :
- Academic Journal
- Accession number :
- 103612959
- Full Text :
- https://doi.org/10.1016/j.reuma.2014.01.009