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Serum levels of glucagon-like peptide (GLP)-1 and GLP-2 in patients with Hashimoto's thyroiditis.
- Source :
-
Journal of Research in Medical Sciences . Feb2015, Vol. 20 Issue 2, p174-177. 4p. - Publication Year :
- 2015
-
Abstract
- Background: The influence of Hashimoto's thyroiditis (HT) with subclinical hypothyroidism or euthyroid status on the alteration of glucagon-like peptide (GLP)-1 and GLP-2 levels remains uncertain. Materials and Methods: Twenty-four untreated HT patients with subclinical hypothyroidism, 24 euthyroid HT patients, and 24 age- and gender-matched controls were enrolled in the study. The levels of GLP-1, GLP-2, glucose, glycated albumin, insulin, thyroid hormone, and thyroid autoantibodies were measured and evaluated. Results: The levels of GLP-1, blood glucose, and triglyceride were higher in HT patients with subclinical hypothyroidism than in controls (all P < 0.05, respectively). However, the above variables, including GLP-2, were similar in euthyroid patients and controls. Neither GLP-1 nor GLP-2 was correlated with thyroid hormone, thyroid autoantibodies or metabolic parameters. Conclusion: The serum levels of GLP-1, not GLP-2, were increased in patients with subclinical hypothyroidism. Our data suggest that subclinical hypothyroidism affects circulating GLP-1 levels. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANALYSIS of variance
*AUTOIMMUNE thyroiditis
*BLOOD testing
*BLOOD pressure measurement
*CHI-squared test
*STATISTICAL correlation
*HYPOTHYROIDISM
*PROBABILITY theory
*RESEARCH funding
*STATISTICAL hypothesis testing
*STATISTICS
*GLUCAGON-like peptide 1
*DATA analysis
*DATA analysis software
*GLUCAGON-like peptides
*MANN Whitney U Test
Subjects
Details
- Language :
- English
- ISSN :
- 17351995
- Volume :
- 20
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Research in Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 103399900