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Synthesis of Antitumor Carbazole-Amonafide Structural Hybrids.
- Source :
-
European Journal of Organic Chemistry . Mar2015, Vol. 2015 Issue 8, p1811-1818. 8p. - Publication Year :
- 2015
-
Abstract
- A facile synthesis of new antitumor [4,5- bc]carbazole-amonafide derivatives is described. These compounds represent a new class of structural hybrids that contain the medicinally important carbazole and amonafide cores. The synthesis involves a Suzuki-Miyaura coupling of bromoamonafide with arylboronic acid reagents followed by the introduction of an azide group and subsequent regiospecific thermal nitrene insertion to yield carbazole-amonafide hybrids in good yields. Preliminary antiproliferative assays against cancer and benign cell lines identified compounds with selective antitumor activity that exhibited submicromolar IC50 values. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2015
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 103395678
- Full Text :
- https://doi.org/10.1002/ejoc.201403549