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Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America . 5/5/2015, Vol. 112 Issue 18, p5613-5618. 6p. - Publication Year :
- 2015
-
Abstract
- The widespread distribution of smartphones, with their integrated sensors and communication capabilities, makes them an ideal platform for point-of-care (POC) diagnosis, especially in resourcelimited settings. Molecular diagnostics, however, have been difficult to implement in smartphones. We herein report a diffractionbased approach that enables molecular and cellular diagnostics. The D3 (digital diffraction diagnosis) system uses microbeads to generate unique diffraction patterns which can be acquired by smartphones and processed by a remote server. We applied the D3 platform to screen for precancerous or cancerous cells in cervical specimens and to detect human papillomavirus (HPV) DNA. The D3 assay generated readouts within 45 min and showed excellent agreement with gold-standard pathology or HPV testing, respectively. This approach could have favorable global health applications where medical access is limited or when pathology bottlenecks challenge prompt diagnostic readouts. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 112
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 103366048
- Full Text :
- https://doi.org/10.1073/pnas.1501815112