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Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital
- Source :
-
FEBS Letters . Jul2003, Vol. 548 Issue 1-3, p17. 4p. - Publication Year :
- 2003
-
Abstract
- The nuclear receptor CAR, a phenobarbital (PB)-responsive transcription factor, translocates into the nucleus of hepatocytes after PB induction. In non-induced mice, CAR forms a physical complex with heat shock protein 90 (HSP90) in the cytoplasm. In response to PB induction, protein phosphatase 2A is recruited to the CAR:HSP90 complex. This recruitment may lead CAR to translocate into the nucleus, consistent with the inhibitions of nuclear CAR accumulation in PB-induced mouse primary hepatocytes by okadaic acid as well as by geldanamycin. [Copyright &y& Elsevier]
- Subjects :
- *NUCLEAR receptors (Biochemistry)
*LIVER cells
*HEAT shock proteins
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 548
- Issue :
- 1-3
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 10323452
- Full Text :
- https://doi.org/10.1016/S0014-5793(03)00720-8