Mechanism-specified 5-exo termini differentiation of a C32-desmethyl C28–C34 aplyronine A analog segment.

Authors :: Bobinski, Thomas P.
Fuchs, Philip L.
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jul2015, Vol. 56 Issue 28, p4155-4158. 4p.
Publication Year :: 2015
Abstract: A new mild, high yielding oxidative cleavage method allows access to a critical lactone aplyronine A analog precursor. Enhanced termini selectivity is achieved, granting access to a previously unavailable C28–C34 C-32-desmethyl actin binding tail fragment via vinyl sulfone polypropionate methodology. [ABSTRACT FROM AUTHOR]

Subjects :: *MACROLIDE antibiotics
*OXIDATION
*LACTONES
*CHEMICAL precursors
*PROPIONATES
*OZONOLYSIS

Language :: English
ISSN :: 00404039
Volume :: 56
Issue :: 28
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 103175410
Full Text :: https://doi.org/10.1016/j.tetlet.2015.04.098

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