Deamination of Betti bases: a facile route to 1-alkyl-2-naphthols and phenols via a metal-free transfer hydrogenation under microwave irradiation.

Authors :: Dutta, Prantu
Pegu, Choitanya Dev
Deb, Mohit L.
Baruah, Pranjal K.
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jul2015, Vol. 56 Issue 27, p4115-4118. 4p.
Publication Year :: 2015
Abstract: A facile route to 1-alkyl-2-naphthols/phenols via deamination followed by a metal-free catalytic transfer hydrogenation of 1-(α-aminoalkyl)-2-naphthols/phenols, commonly called Betti bases under microwave irradiation has been developed. Hantzsch 1,4-dihydropyridine is used as the reductant. A mechanistic proposal involving elimination–addition mechanism is described. The reaction is simple, clean, and offers very good yields of products. [ABSTRACT FROM AUTHOR]

Subjects :: *NAPHTHOL
*PHENOLS
*HYDROGENATION
*MICROWAVES
*DIHYDROPYRIDINE
*ELIMINATION reactions

Language :: English
ISSN :: 00404039
Volume :: 56
Issue :: 27
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 103116777
Full Text :: https://doi.org/10.1016/j.tetlet.2015.05.031

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