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NUP98/11p15 translocations affect CD34+ cells in myeloid and T lymphoid leukemias.
- Source :
-
Leukemia Research . Jul2015, Vol. 39 Issue 7, p769-772. 4p. - Publication Year :
- 2015
-
Abstract
- We assessed lineage involvement by NUP98 translocations in myelodysplastic syndromes (MDS), acute myeloid leukaemia (AML), and T-cell acute lymphoblastic leukaemia (T-ALL). Single cell analysis by FICTION (Fluorescence Immunophenotype and Interphase Cytogenetics as a Tool for Investigation of Neoplasms) showed that, despite diverse partners, i.e. NSD1 , DDX10 , RAP1GDS1 , and LNP1 , NUP98 translocations always affected a CD34+/CD133+ hematopoietic precursor. Interestingly the abnormal clone included myelomonocytes, erythroid cells, B- and T- lymphocytes in MDS/AML and only CD7+/CD3+ cells in T-ALL. The NUP98-RAP1GDS1 affected different hematopoietic lineages in AML and T-ALL. Additional specific genomic events, were identified, namely FLT3 and CEBPA mutations in MDS/AML, and NOTCH1 mutations and MYB duplication in T-ALL. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01452126
- Volume :
- 39
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Leukemia Research
- Publication Type :
- Academic Journal
- Accession number :
- 103001682
- Full Text :
- https://doi.org/10.1016/j.leukres.2015.04.014