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Severe Vitamin D Deficiency May be an Additional Cofactor for the Occurrence of Alcoholic Steatohepatitis.
- Source :
-
Alcoholism: Clinical & Experimental Research . Jun2015, Vol. 39 Issue 6, p1027-1033. 7p. - Publication Year :
- 2015
-
Abstract
- Background Among its pleiotropic effects, vitamin D may protect the liver from fibrosis and/or inflammation. However, the impact of vitamin D on liver pathology in hepatitis C remains unclear, and very few studies including alcoholic patients with liver pathologies have been performed. Here we compared the levels of 25- OH vitamin D in the blood of alcoholic patients with the occurrence of alcoholic steatohepatitis (ASH) or bridging fibrosis. Methods One hundred and one alcoholic patients were included. All the patients received a liver biopsy, and the levels of 25- OH vitamin D were evaluated with the Liaison 25-OH vitamin D assay. Logistic regression analyses were performed to obtain predictive factors of liver histology. Results Among alcoholic patients, 40.6% presented ASH and 39.6% presented bridging fibrosis. A severe deficiency in 25-OH vitamin D (<10 ng/ml) was seen in 60.4% of patients. This deficiency was frequent in patients with ASH (85.4%) and in those with bridging fibrosis (80%) but was independently associated only with ASH (odds ratio = 8.46 [95% confidence interval 2.05 to 34.89], p = 0.003). Conclusions In alcoholic patients, a severe deficiency in 25- OH vitamin D was independently associated with the occurrence of ASH. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COMPLICATIONS of alcoholism
*FIBROSIS
*BIOLOGICAL assay
*BIOPSY
*CHI-squared test
*CONFIDENCE intervals
*FATTY liver
*RESEARCH funding
*T-test (Statistics)
*VITAMIN D
*VITAMIN D deficiency
*LOGISTIC regression analysis
*CROSS-sectional method
*DESCRIPTIVE statistics
*ODDS ratio
*MANN Whitney U Test
*DISEASE complications
*DIAGNOSIS
Subjects
Details
- Language :
- English
- Volume :
- 39
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Alcoholism: Clinical & Experimental Research
- Publication Type :
- Academic Journal
- Accession number :
- 102990539
- Full Text :
- https://doi.org/10.1111/acer.12728