Spondyloarthropathy: interleukin 23 and disease modification.

The article comments on how cytokine interleukin 23 drives seronegative spondyloarthropathies, a diverse cluster of diseases that include the forms of arthritis, reactive arthritis associated with a defined range of specific pathogens and ankylosing spondylitis. Interleukin 23 was shown to be a powerful proinflammatory factor central to immune-mediated inflammation