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Cytoskeletal Requirements for Hepatitis C Virus (HCV) RNA Synthesis in the HCV Replicon Cell Culture System.
- Source :
-
Journal of Virology . Apr2003, Vol. 77 Issue 7, p4401. 8p. 2 Diagrams, 10 Graphs. - Publication Year :
- 2003
-
Abstract
- Hepatitis C virus (HCV) induces microtubule aggregates in infected hepatocytes. To determine if cytoskeletal elements are important for HCV RNA synthesis, we examined the effect of cytoskeleton inhibitors on HCV replicon transcription in Huh7 cells. The data demonstrate that HCV replication complex-mediated RNA synthesis requires microtubule and actin polymerization. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEPATITIS C virus
*MICROTUBULES
*LIVER cells
Subjects
Details
- Language :
- English
- ISSN :
- 0022538X
- Volume :
- 77
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Journal of Virology
- Publication Type :
- Academic Journal
- Accession number :
- 10298523
- Full Text :
- https://doi.org/10.1128/JVI.77.7.4401-4408.2003