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The Non-Proliferative Nature of Ascidian Folliculogenesis as a Model of Highly Ordered Cellular Topology Distinct from Proliferative Epithelia.

Authors :
Azzag, Karim
Chelin, Yoann
Rousset, François
Le Goff, Emilie
Martinand-Mari, Camille
Martinez, Anne-Marie
Maurin, Bernard
Daujat-Chavanieu, Martine
Godefroy, Nelly
Averseng, Julien
Mangeat, Paul
Baghdiguian, Stephen
Source :
PLoS ONE. May2015, Vol. 10 Issue 5, p1-19. 19p.
Publication Year :
2015

Abstract

Previous studies have addressed why and how mono‐stratified epithelia adopt a polygonal topology. One major additional, and yet unanswered question is how the frequency of different cell shapes is achieved and whether the same distribution applies between non-proliferative and proliferative epithelia. We compared different proliferative and non-proliferative epithelia from a range of organisms as well as Drosophila melanogaster mutants, deficient for apoptosis or hyperproliferative. We show that the distribution of cell shapes in non‐proliferative epithelia (follicular cells of five species of tunicates) is distinctly, and more stringently organized than proliferative ones (cultured epithelial cells and Drosophila melanogaster imaginal discs). The discrepancy is not supported by geometrical constraints (spherical versus flat monolayers), number of cells, or apoptosis events. We have developed a theoretical model of epithelial morphogenesis, based on the physics of divided media, that takes into account biological parameters such as cell‐cell contact adhesions and tensions, cell and tissue growth, and which reproduces the effects of proliferation by increasing the topological heterogeneity observed experimentally. We therefore present a model for the morphogenesis of epithelia where, in a proliferative context, an extended distribution of cell shapes (range of 4 to 10 neighbors per cell) contrasts with the narrower range of 5-7 neighbors per cell that characterizes non proliferative epithelia. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
19326203
Volume :
10
Issue :
5
Database :
Academic Search Index
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
102969478
Full Text :
https://doi.org/10.1371/journal.pone.0126341