225 Nutritional status of children with cystic fibrosis (CF) in Russia and neighboring territories.

Objectives Our previous abstract failed to elucidate if early diagnosis of CF by neonatal screening which had been introduced in Russia since 2006 had a positive influence on the nutritional status of CF children. We suppose that the higher portion of patients with low z-scores is a result of early diagnose but inadequate treatment in some distant Russian regions (Caucasus). The aim of the study was to determine the nutritional status of CF children in Russian regions versus some neighboring territories and Caucasus region. Methods 61 children with CF from Moscow region (112 measurements), 64 children (141 measurements) from other Russian regions, 19 children from Ukraine, Kazakhstan and Moldova, receiving treatment in Moscow (41 measurements), and 25 children from Caucasus (40 measurements). Weight and height of CF children were recorded according to standard methods and expressed as standard deviation scores (z-score) and percentiles adjusted for age and gender using WHOAnthro- and WHOAnthroPlus programs. Results Mann–Whitney test showed statistically significant differences in z-scores: weight/age (p<0.001) and body length/age (p<0.001) in Caucasus group versus Moscow region; weight/age (p<0.001) and body length/age in Ukraine group (p<0.001) versus Moscow region; body length/age in Moscow (p<0.001) was better versus other Russian regions. Conclusion Children with CF in Moscow and Russian regions have relatively good nutritional status compared with Caucasus region and Ukraine/Kazakhstan/Moldavian patients with CF, which require better primary care in these regions. [ABSTRACT FROM AUTHOR]