Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus.

Authors :: van der Linden, J. W. M.
Arendrup, M. C.
Warris, A.
Lagrou, K.
Pelloux, H.
Hauser, P. M.
Chryssanthou, E.
Mellado, E.
Kidd, S. E.
Tortorano, A. M.
Dannaoui, E.
Gaustad, P.
Baddley, J. W.
Uekötter, A.
Lass-Flörl, C.
Klimko, N.
Moore, C. B.
Denning, D. W.
Pasqualotto, A. C.
Kibbler, C.
Source :: Emerging Infectious Diseases. Jun2015, Vol. 21 Issue 6, p1041-1044. 4p. 1 Diagram, 2 Charts, 1 Graph.
Publication Year :: 2015
Abstract: To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles. [ABSTRACT FROM AUTHOR]

Subjects :: *DISEASE prevalence
*ASPERGILLUS fumigatus
*AZOLES
*HETEROCYCLIC compounds
*DRUG resistance

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