Tetraphenylborate Salt of Bambuterol (Bambec): Synthesis, Characterization and X-ray Structure of N-(2-(3,5-bis((dimethylcarbamoyl)oxy)phenyl)-2-hydroxyethyl)-2-methylpropan-2-aminium tetraphenylborate.

The title compound tetraphenylborate salt of bambuterol (Bambec), N-(2-(3,5-bis((dimethylcarbamoyl)oxy)phenyl)-2-hydroxyethyl)-2-methylpropan-2-aminium tetraphenylborate ( 4), was prepared in 73 % yield by the reaction of 5-(2-( tert-butylamino)-1-hydroxyethyl)-1,3-phenylene bis(dimethylcarbamate) hydrochloride (bambuterol hydrochloride) ( 2) with sodium tetraphenylborate ( 3) in deionized water, at ambient temperature, through anion exchange reaction. The structure of the title borate salt was characterized by IR, mass and H NMR analyses. Colorless crystals of 4 suitable for an X-ray structural analysis were obtained by slow evaporation from acetonitrile. Compound 4 crystallizes in the monoclinic, space group P2/ c, with a = 8.8931 (2) Å, b = 20.4639 (6) Å, c = 21.4393 (6) Å, β = 93.640 (2)°, V = 3893.81 (18) Å, Z = 4. Graphical Abstract: Synthesis, characterization and X-ray structure of tetraphenylborate salt of bambuterol (Bambec), the drug for the treatment of asthma, bronchospasm, emphysema, and chronic obstructive pulmonary disease. [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]