Back to Search
Start Over
Acyclovir in pityriasis rosea: An observer-blind, randomized controlled trial of effectiveness, safety and tolerability.
- Source :
-
Indian Dermatology Online Journal . May/Jun2015, Vol. 6 Issue 3, p181-184. 4p. - Publication Year :
- 2015
-
Abstract
- Background: Pityriasis rosea (PR) is an acute inflammatory dermatosis. The association of human herpes virus 6 and 7 suggests the utility of use of antiviral agents in this disease. Aims and Objectives: To evaluate the effectiveness and safety of acyclovir in the treatment of PR. Methods: An observer-blind, randomized (1:1), parallel group, add-on trial was conducted on 24 adult patients with PR. Subjects of both Group A and B received the standard of care in the form of cetirizine 10 mg OD and calamine. Group A in addition received acyclovir 400 mg tablets thrice daily for 7 days. Both groups were followed up for four consecutive weeks for assessment of effectiveness and adverse events. Results: Group A complained of significantly fewer new lesions than Group B (P = 0.046). A complete response was obtained in all patients of Group A and 83% patients of Group B at the end of the follow up period. There was significant reduction in both lesional score and pruritus at second week follow-up in Group A and third week follow-up in Group B (P < 0.05). Minor adverse effects were observed in both treatment arms. Conclusion: Acyclovir offered rapid resolution of clinical severity of PR from second week onwards without significantly increased adverse events as compared to supportive therapy alone. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22295178
- Volume :
- 6
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Indian Dermatology Online Journal
- Publication Type :
- Academic Journal
- Accession number :
- 102629255
- Full Text :
- https://doi.org/10.4103/2229-5178.156389