H-Adamantylphosphinates as Universal Precursors of P-Stereogenic Compounds.

A new family of H-adamantjdphosphinates as universal precursors of P-stereogenic Ugands was obtained in one step from commercial chlorophosphines. Both enantiomers of these air- and moisture-stable intermediates can easily be separated by semipreparative chiral HPLC on a gram scale and individually undergo stereoselective transformations to afford each enantiomer of a set of P-stereogenic compounds such as secondary phosphine oxides and boron-protected monophosphines. [ABSTRACT FROM AUTHOR]