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TGF-β signalling prevents pancreatic beta cell death after proliferation.
- Source :
-
Cell Proliferation . Jun2015, Vol. 48 Issue 3, p356-362. 7p. - Publication Year :
- 2015
-
Abstract
- Objectives Maintenance of functional beta cell mass is critical for prevention of diabetes. The transforming growth factor-beta ( TGF-β) receptor signalling pathway plays an essential role in pancreatic development. However, its involvement in control of post-natal beta cell growth has only been recently reported. Materials and methods Here, we studied the role of TGF-β receptor signalling in beta cell proliferation after 50% partial pancreatectomy ( PPx), using beta cell-specific TGF-β receptor II ( TBR2)-mutated mice. Results Consistent with previous reports, we found that inhibition of TGF-β receptor signalling in beta cells resulted in slightly higher beta cell mass 1 week after PPx, due to greater beta cell proliferation. However, beta cell mass in these beta cell-specific TBR2-mutated mice significantly decreased by 12 weeks after PPx, resulting from increase in beta cell apoptosis. Conclusions Our data thus suggest that TGF-β receptor signalling may be required for prevention of beta cell death after proliferation, and highlight this pathway as an essential regulator during post-natal beta cell homoeostasis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09607722
- Volume :
- 48
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Cell Proliferation
- Publication Type :
- Academic Journal
- Accession number :
- 102482600
- Full Text :
- https://doi.org/10.1111/cpr.12183