Iron-Catalyzed α-Methylenation of Ketones with N, N-Dimethylacetamide: An Approach for α,β-Unsaturated Carbonyl Compounds.

In this study, we developed a general iron-catalyzed α-methylenation of ketones by using N,N-dimethylacetamide as the one-carbon source. Various ketones, including aryl and alkyl ketones, enones, and dicarbonyl compounds were well tolerated to yield the corresponding α,β-unsaturated carbonyl compounds in the presence of an iron catalyst, peroxides, and N,N-dimethylacetamide under aerobic conditions. [ABSTRACT FROM AUTHOR]