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Iron(II)-Promoted Synthesis of 2-Aminothiazoles via C--N Bond Formation from Vinyl Azides and Potassium Thiocyanate.

Iron(II)-Promoted Synthesis of 2-Aminothiazoles via C--N Bond Formation from Vinyl Azides and Potassium Thiocyanate.

Authors :
Zhang, Guolin
Chen, Binhui
Guo, Xiao
Guo, Shanshan
Yu, Yongping
Source :
Advanced Synthesis & Catalysis. Mar2015, Vol. 357 Issue 5, p1065-1069. 5p.
Publication Year :
2015

Abstract

A simple protocol to prepare the privileged 2-aminothiazoles promoted by ferrous sulfate heptahydrate via C-N bond formation from vinyl azides and commercially available potassium thiocyanate has been developed. A wide range of vinyl azides are tolerated to afford the expected polysubstituted 2-aminothiazoles in reasonably good yields. The use of the non-toxic substrates and catalyst renders the reaction more environmentally friendly than traditional approaches. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16154150
Volume :
357
Issue :
5
Database :
Academic Search Index
Journal :
Advanced Synthesis & Catalysis
Publication Type :
Academic Journal
Accession number :
102376798
Full Text :
https://doi.org/10.1002/adsc.201400856