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Childhood body mass index and wheezing disorders: a systematic review and meta-analysis.
- Source :
-
Pediatric Allergy & Immunology . Feb2015, Vol. 26 Issue 1, p62-72. 11p. - Publication Year :
- 2015
-
Abstract
- Background: It has been claimed that overweight/obesity, childhood asthma and wheezing disorders are associated, although the results of observational studies have remained inconsistent. We conducted a systematic review and meta-analysis to investigate this. Methods: An online search of published papers linking childhood asthma and wheezing with overweight/obesity up to May 2014 using EMBASE and MEDLINE medical research databases was carried out. Summary odds ratios (OR) were estimated using random-effects models. Subgroup meta-analyses were performed to assess the robustness of risk associations and between-study heterogeneity. Results: A total of 38 studies comprising 1,411,335 participants were included in our meta-analysis. The summary ORs of underweight (<5th percentile), overweight (>85th to <95th percentile) and obesity (⩾95th percentile) were 0.85 (95% CI: 0.75 to 0.97; p = 0.02), 1.23 (95% CI: 1.17 to 1.29; p < 0.001) and 1.46 (95% CI: 1.36 to 1.57, p < 0.001), respectively. Heterogeneity was significant and substantial in all three weight categories, and not accounted for by pre-defined study characteristics. Conclusion: Our results suggest that underweight is associated with a reduced risk of childhood asthma, and overweight and obesity are associated with an increased risk of childhood asthma. Although our findings assert that overweight/obesity and childhood asthma are associated, the causal pathway and temporal aspects of this relationship remain unanswered and deserve further epidemiological investigation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09056157
- Volume :
- 26
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Pediatric Allergy & Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 102210774
- Full Text :
- https://doi.org/10.1111/pai.12321