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Absence of antidiabetic activity in some novel thiazolidinone derivatives.
- Source :
-
Journal of Pharmaceutical Negative Results . Jan-Dec2013, Vol. 4 Issue 1, p39-45. 7p. - Publication Year :
- 2013
-
Abstract
- Aim: It was aimed to synthesise some novel thiazolidinone derivatives and assess them for antidiabetic activity. Material and Methods: A series of substituted 5-ethylidene- 2-(phenylimino) thiazolidin-4-ones were prepared by using phenylthiourea (I) as a starting material. Phenylthiourea on reaction with ethylchloroacetate, in the presence of ethanol and fused sodium acetate, gave 2-(phenylimino) thiazolidin-4-one (II), and 2-(phenylimino) thiazolidin-4-one on further reaction with substituted benzaldehyde gave substituted 5-ethylidene-2- (phenylimino) thiazolidin-4-one (III - XVIII). The synthesized compounds were authenticated on the basis of elemental analysis, IR, 1H NMR, and Mass spectral analysis and some of the compounds were selected on the basis of a literature review, to evaluate them for their antidiabetic activity. Results and Conclusion: All The tested compounds 5-(4-fluorobenzylidene)-2-(phenylimino) thiazolidin-4-on (VII) and 5-(4-Methylbenzylidene)-2-(phenylimino)thiazolidin-4-one (X), 5-(2, 4-dinitrobenzylidene)-2-(phenylamino) thiazolidin-4-one (XVII) were found to be ineffective in lowering the blood glucose level. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09769234
- Volume :
- 4
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Pharmaceutical Negative Results
- Publication Type :
- Academic Journal
- Accession number :
- 102149020
- Full Text :
- https://doi.org/10.4103/0976-9234.116768