Research progress in interleukin 28B polymorphisms in infection and treatment of chronic hepatitis B virus.

The infection/clearance and antiviral therapy of hepatitis B virus (HBV) are affected by various factors, such as the host, virus, and environment. Recent studies have proven that interleukin 28B (IL - 28B) polymorphisms are highly associated with the clearance and antiviral therapy of hepatitis C virus. Since then, great attention has been paid to the role of IL - 28B genetic variations in chronic hepatitis B (CHB), with a research focus on the loci rs12979860, rs12980275, and rs8099917. This paper reviews the role of IL - 28B polymorphisms in the infection/clearance of HBV and interferon therapy of CHB. Despite the conflicting findings, IL - 28B polymorphisms are considered to have a potential clinical value in the field of CHB. [ABSTRACT FROM AUTHOR]