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Development and evaluation of a new interferon-gamma release assay for the diagnosis of tuberculosis infection in HIV-infected individuals in China.
- Source :
-
Infectious Diseases . 2015, Vol. 47 Issue 4, p238-243. 6p. 1 Diagram, 3 Charts, 1 Graph. - Publication Year :
- 2015
-
Abstract
- Background: Human immunodeficiency virus (HIV)-infected individuals are at high risk of contracting tuberculosis (TB) disease, and current methods for diagnosing TB infection are less effective in this population. We developed and evaluated a new interferon-gamma release assay (IGRA), named A.TB, in HIV-infected individuals, with and without active TB, in a setting of high TB burden and low HIV prevalence. Methods: A total of 255 subjects were divided into 3 groups according to their HIV and TB status: HIV + without active TB (n = 123), HIV +/TB + (n = 79), and HIV-/TB + (n = 65). The A.TB assay was performed in parallel with the QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST). Results: The positive rate was 59.3% (n = 123) by A.TB and 53.8% (n = 106) by QFT-GIT. We observed a strong concordance of 81.2% (k = 0.612) between the two IGRAs. The QFT-GIT results were affected by low CD4+ cell count (p= 0.013), while A.TB results were not. A.TB was also performed in patients with active TB (n = 65) and patients with active TB and HIV co-infection (n = 79). The sensitivity of A.TB in these groups was 80.0% and 81.0%, respectively. Conclusion: The A.TB results were not affected by low CD4+ cell count in the co-infected cohort. With further evaluation,A.TB may prove to be a valuable tool for diagnosing TB in HIV-infected patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INTERFERON gamma release tests
*TUBERCULOSIS diagnosis
*HIV-positive persons
*TUBERCULIN test
*IMMUNODEFICIENCY
*DIAGNOSIS of HIV infections
*ANTITUBERCULAR agents
*HIV infection epidemiology
*COMPARATIVE studies
*FISHER exact test
*HIV
*LONGITUDINAL method
*MYCOBACTERIUM tuberculosis
*STATISTICS
*CYTOMETRY
*DATA analysis
*DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 23744235
- Volume :
- 47
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 102110012
- Full Text :
- https://doi.org/10.3109/00365548.2014.988749