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The histone deacetylase Rpd3/Sin3/Ume6 complex represses an acetate-inducible isoform of VTH2 in fermenting budding yeast cells.
- Source :
-
FEBS Letters . Apr2015, Vol. 589 Issue 8, p924-932. 9p. - Publication Year :
- 2015
-
Abstract
- The tripartite Rpd3/Sin3/Ume6 complex represses meiotic isoforms during mitosis. We asked if it also controls starvation-induced isoforms. We report that VTH1/VTH2 encode acetate-inducible isoforms with extended 5′-regions overlapping antisense long non-coding RNAs. Rpd3 and Ume6 repress the long isoform of VTH2 during fermentation. Cells metabolising glucose contain Vth2, while the protein is undetectable in acetate and during sporulation. VTH2 is a useful model locus to study mechanisms implicating promoter directionality, lncRNA transcription and post-transcriptional control of gene expression via 5′-UTRs. Since mammalian genes encode transcript isoforms and Rpd3 is conserved, our findings are relevant for gene expression in higher eukaryotes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HISTONE deacetylase
*ACETATES
*MEIOSIS
*MITOSIS
*NON-coding RNA
*GENE expression
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 589
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 101918693
- Full Text :
- https://doi.org/10.1016/j.febslet.2015.02.022