Synthesis of 2-(chloro(methoxy, morpholino)methyl)-hexahydropyrimidothieno[3,2- c]azocines and tetrahydrospiro[pyrido[4,5']thieno[2,3- d]pyrimidines].

[Figure not available: see fulltext.] 2-(Chloromethyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3- d]pyrimidin-4(3 Н)-ones reacted with acetylenedicarboxylate ester, methyl propiolate or acetylacetylene, forming mixtures of 2-(chloromethyl)-5,6,7,10-tetrahydropyrimido[5',4':4,5]thieno[3,2- d]azocin-4(3 Н)-ones and 2'-chloromethyl-6'-methylidene-2,3-dihydro-1 Н-spiro[pyrido[4,5']thieno[2,3- d]pyrimidin]-4'(3' H)-ones in various ratios. Analogous products were also obtained in the reaction of 2-(methoxymethyl) derivative with methyl propiolate, while using 2-[(morpholin-4-yl)-methyl] derivative in a similar reaction led to the formation of a more complex product mixture. [ABSTRACT FROM AUTHOR]