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Underdiagnosis of Obstructive Sleep Apnoea in Peripheral Arterial Disease.
- Source :
-
Respiration . Mar2015, Vol. 89 Issue 3, p214-220. 7p. 2 Charts, 1 Graph. - Publication Year :
- 2015
-
Abstract
- Background: Obstructive sleep apnoea (OSA) has interdependently been related to the onset and progression of a large portion of atherosclerotic cardiovascular disorders. In due consideration of OSA-mediated endothelial dysfunction, its impact on peripheral artery disease is conceivable, but undefined. Objectives: The aim of this study was to identify the prevalence of OSA in a lower extremity artery disease (LEAD) study population. Methods: A total of 91 patients receiving in- and outpatient treatment for LEAD were included in this prospectively conducted trial. In addition to an angiological examination, all patients underwent nocturnal screening for sleep-disordered breathing by use of SOMNOcheck micro® (SC micro) and - depending on the results obtained - polysomnography. Results: Patients were principally late middle-aged (69.3 ± 10.8 years), male (71.4%) and slightly overweight (BMI 26.8 ± 3.9). Overnight screening determined a sleep apnoea prevalence of 78.0%, of which 90.1% exhibited a predominantly obstructive genesis. The mean apnoea-hypopnoea index (AHI; events/h) and oxygen desaturation index (events/h) averaged 11.8 ± 13.4 and 8.9 ± 14.2, respectively. The individual AHI categories of non-pathological (<5), mild (5 to <15), moderate (15 to <30) and severe sleep apnoea (≥30) accounted for 22.0, 59.3, 13.2 and 5.5%, respectively. A distributive examination of AHI within LEAD severity groups evinced a significant association (p = 0.047). In cases of at least moderate sleep apnoea (AHI ≥15) polysomnography was performed (n = 17, 18.7% of the whole collective). Correlative analysis revealed a significant correlation between values obtained by SC micro recording and polysomnography, establishing the diagnostic accuracy of the screening results. Conclusions: OSA exhibits an important prevalence of 70.3% in LEAD patients with prior undiagnosed sleep-disordered breathing, indicating major OSA unawareness in this cardiovascular cohort. However, the impact of OSA treatment on LEAD propagation remains to be determined. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- *PERIPHERAL vascular disease treatment
*ACADEMIC medical centers
*ACTIVE oxygen in the body
*CARDIOVASCULAR diseases risk factors
*CHI-squared test
*DIAGNOSIS
*EPIDEMIOLOGICAL research
*GAIT in humans
*LEG
*LIFE skills
*LONGITUDINAL method
*PERIPHERAL vascular diseases
*PHYSICAL diagnosis
*PROBABILITY theory
*QUESTIONNAIRES
*SLEEP apnea syndromes
*SMOKING
*STATISTICAL hypothesis testing
*STATISTICS
*T-test (Statistics)
*COMORBIDITY
*POLYSOMNOGRAPHY
*DATA analysis
*BODY mass index
*RETROSPECTIVE studies
*SEVERITY of illness index
*ANKLE brachial index
*DATA analysis software
*DESCRIPTIVE statistics
*KRUSKAL-Wallis Test
*DISEASE complications
*DISEASE risk factors
PERIPHERAL vascular disease diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 00257931
- Volume :
- 89
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Respiration
- Publication Type :
- Academic Journal
- Accession number :
- 101565513
- Full Text :
- https://doi.org/10.1159/000371355