367. Intervene to prevent osteoporosis in long-term kidney graft recipients.

Objective: To find out the frequency and predictors of osteoporotic fractures in late kidney graft patients. Methodology: Changes in spinal, hip, and total body bone mineral density were assessed using a DEXA Hologic QRD 1000 scanner and fractures were quantified in all kidney graft patients presenting for routine evaluation with a minimal follow-up of 5 years after transplantation (mean follow-up, 8.5 years). Biochemical markers of bone metabolism and clinical and dietary intake data were collected. Results: Fifty-none renal graft recipients were enrolled. Osteoporosis, according to the World Health Organization definition, was observed in 31 patients (53% of the total population) and fractures occurred in 26 patients (44% of the total population and 51.6% of patients with osteoporosis). Femoral neck bone mineral density was positively correlated with patient weight and cyclosporine current dosage. Steroid cumulative dosage correlated only to lumbar spine Z score. Dietary calcium, serum 25 hydroxyvitamin D, parathyroid hormone, and urinary N-telopeptides excretion were normal. Conclusion: There is a substantial prevalence of osteoporosis and fractures among very long-term kidney graft recipients. [ABSTRACT FROM AUTHOR]