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Integrated genome-wide association findings implicate a neurodevelopmental network involved in neurite outgrowth in attention deficit hyperactivity disorder (ADHD)
- Source :
-
European Child & Adolescent Psychiatry . Jun2010, Vol. 19, pS47-S47. 1/3p. - Publication Year :
- 2010
-
Abstract
- Introduction and objectives: Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neuropsychiatric disorder observed in children and adults. We have investigated the presence of genomic convergence in the top findings of the five published genome- wide association studies (GWAS) of ADHD. Methods: We conducted bioinformatics analyses and a systematic literature analysis of 85 ADHD candidate genes from the five GWAS that contained at least one single nucleotide polymorphism (SNP) yielding an association P value < 1.00E-04. Results and discussion: We found that 44 of the 85 top ADHD candidate genes fit into a network that links several neuronal cell membrane proteins with downstream-acting adaptor proteins and neuronal cytoskeleton/extracellular matrix associated proteins. Acting together, these proteins are involved in directed neurite outgrowth. Moreover, a number of proteins in the identified network are directly modulated by stimulants, the most commonly used psychopharmacological treatment for ADHD. Conclusion: We have identified a protein network that may provide an important contribution to our understanding of the molecular basis of ADHD and give clues to specific genes that should be tested in future studies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10188827
- Volume :
- 19
- Database :
- Academic Search Index
- Journal :
- European Child & Adolescent Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 101346277
- Full Text :
- https://doi.org/10.1007/s00787-010-0117-5