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Integrated genome-wide association findings implicate a neurodevelopmental network involved in neurite outgrowth in attention deficit hyperactivity disorder (ADHD)

Authors :
Poelmans, Geert
Pauls, David L.
Buitelaar, Jan K.
Franke, Barbara
Source :
European Child & Adolescent Psychiatry. Jun2010, Vol. 19, pS47-S47. 1/3p.
Publication Year :
2010

Abstract

Introduction and objectives: Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neuropsychiatric disorder observed in children and adults. We have investigated the presence of genomic convergence in the top findings of the five published genome- wide association studies (GWAS) of ADHD. Methods: We conducted bioinformatics analyses and a systematic literature analysis of 85 ADHD candidate genes from the five GWAS that contained at least one single nucleotide polymorphism (SNP) yielding an association P value < 1.00E-04. Results and discussion: We found that 44 of the 85 top ADHD candidate genes fit into a network that links several neuronal cell membrane proteins with downstream-acting adaptor proteins and neuronal cytoskeleton/extracellular matrix associated proteins. Acting together, these proteins are involved in directed neurite outgrowth. Moreover, a number of proteins in the identified network are directly modulated by stimulants, the most commonly used psychopharmacological treatment for ADHD. Conclusion: We have identified a protein network that may provide an important contribution to our understanding of the molecular basis of ADHD and give clues to specific genes that should be tested in future studies. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10188827
Volume :
19
Database :
Academic Search Index
Journal :
European Child & Adolescent Psychiatry
Publication Type :
Academic Journal
Accession number :
101346277
Full Text :
https://doi.org/10.1007/s00787-010-0117-5