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Aptasensor for Staphylococcus Enterotoxin B Detection Using High SNR Piezoresistive Microcantilevers.
- Source :
-
Journal of Microelectromechanical Systems . Oct2014, Vol. 23 Issue 5, p1054-1062. 9p. - Publication Year :
- 2014
-
Abstract
- This paper proposes and demonstrates aptasensors for the detections of staphylococcus enterotoxin B (SEB) both in buffer and skim milk by using thiol-modified piezoresistive microcantilever. With attempts to optimize the design and fabrication processes of the microcantilever, the signal-to-noise rate of the aptasensor was greatly improved and an output voltage shift smaller than 1 \(\mu \) V was successfully obtained. By immobilizing thiol-modified target aptamers onto the nanogold-coated surface of the sensing cantilevers, different concentrations of SEB were detected with a wide detection range of 6-300 ng/mL in buffer, as well as in skim milk. All the experimental results indicate that the piezoresistive cantilever-based aptasensor has sufficient sensitivity to detect food contaminants and might provide an economical platform for on-site detections of different toxicants with the advantages of portability, high sensitivity, and rapid response. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10577157
- Volume :
- 23
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Microelectromechanical Systems
- Publication Type :
- Academic Journal
- Accession number :
- 101290627
- Full Text :
- https://doi.org/10.1109/JMEMS.2014.2345666