m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.

The article focuses on the role of the N6methyladenosine (m6A) transferase Mettl3 in regulating the state transitions of naïve and primed pluripotency toward cell differentiation. It states a small interfering RNA screen was conducted against transcriptional regulators and tested if a primed EpiSC harboring a green fluorescent protein reporter knockin allele might rely on some of the factors. It comments that M6A messenger RNA methylation was a regulator acting at molecular switches.