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Hepatocyte growth factor: A regulator of inflammation and autoimmunity.

Authors :
Molnarfi, Nicolas
Benkhoucha, Mahdia
Funakoshi, Hiroshi
Nakamura, Toshikazu
Lalive, Patrice H.
Source :
Autoimmunity Reviews. Apr2015, Vol. 14 Issue 4, p293-303. 11p.
Publication Year :
2015

Abstract

Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases. HGF was reported to prevent and attenuate disease progression by influencing multiple pathophysiological processes involved in inflammatory and immune response, including cell migration, maturation, cytokine production, antigen presentation, and T cell effector function. In this review, we discuss the actions and mechanisms of HGF in inflammation and immunity and the therapeutic potential of this factor for the treatment of inflammatory and autoimmune diseases. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15689972
Volume :
14
Issue :
4
Database :
Academic Search Index
Journal :
Autoimmunity Reviews
Publication Type :
Academic Journal
Accession number :
101092936
Full Text :
https://doi.org/10.1016/j.autrev.2014.11.013