İdrar monosit kemoatraktan protein-1'in tip II diyabetik nefropatili hastaların renal fonksiyonlarının takibinde kullanımı ve renal hasarın değerlendirilmesinde prognostik belirteç olarak değeri.

Objective: The aim of this study was to determine the relationship between modified diet in renal disease (MDRD) glomerular filtration rate (GFR) and ratio of urinary monocyte chemoattractant protein-1 (MCP-1)/ creatinin (urinary MCP-1) and urine albumin/creatinine rates (urine albumin) in type 2 diabetic nephropaty patients who were in different stages and to assess the use of urinary MCP-1 as a prognostic indicator in monitoring renal functions of these patients and in renal injury. Methods: This cross-sectional study included 100 diabetic patients (48 females, 52 males). Patients were randomized into 3 groups based on renal function determined by urine albumin. Patients who had urine albumin <30 mg/g were defined as normoalbuminuric (NOA) (n=20); those who had 30-300 mg/g urine albumin were referred as microalbuminuric (MIA) (n=51) and patients with urine albumin >300 mg/g were defined as macroalbuminuric (MAA) (n=29). Three groups were measured and compared. Results: Inter-group assessment was performed by using "Oneway ANOVA" and "Kruskal-Wallis" tests and significant differences have been found between urinary MCP-1 in three groups. Urinary MCP-1 was found to be 156.02 pg/g (41.28-478.60) in NOA group; 174.99 pg/g (100.89647.18) in MIA group and 245.71 pg/g (96.78-724.59) in MAA group. Urinary MCP-1 levels increased by increasing of albuminuria and by deterioration of renal function. Correlation of urinary MCP-1 was positive with urine albumin (r=0.389; p<0.0001) while was negative with MDRD GFR (r=0.314; p=0.001). Conclusion: Our findings demonstrated that urinary MCP-1 is related with urine albumin and MDRD GFR in patients with type 2 diabetic nephropathy. Thus, urinary MCP-1 could be used in monitoring renal functions of patients and serve as a prognostic indicator in assessment of renal injury of these patients. [ABSTRACT FROM AUTHOR]