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Intrinsic plasticity: an emerging player in addiction.
- Source :
-
Nature Reviews Neuroscience . Mar2015, Vol. 16 Issue 3, p173-184. 12p. - Publication Year :
- 2015
-
Abstract
- Exposure to drugs of abuse, such as cocaine, leads to plastic changes in the activity of brain circuits, and a prevailing view is that these changes play a part in drug addiction. Notably, there has been intense focus on drug-induced changes in synaptic excitability and much less attention on intrinsic excitability factors (that is, excitability factors that are remote from the synapse). Accumulating evidence now suggests that intrinsic factors such as K+ channels are not only altered by cocaine but may also contribute to the shaping of the addiction phenotype. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NEUROPLASTICITY
*DRUGS of abuse
*CENTRAL nervous system
*NEURONS
*NEURAL circuitry
Subjects
Details
- Language :
- English
- ISSN :
- 1471003X
- Volume :
- 16
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Nature Reviews Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 101062549
- Full Text :
- https://doi.org/10.1038/nrn3877